Progress in the genetics of restless legs syndrome: the path ahead in the era of whole-genome sequencing

Sleep

article

Akçimen, Fulya¹  Dion, Patrick A²  Rouleau, Guy A¹ 

[1] Department of Human Genetics, McGill University;Montréal Neurological Institute-Hospital, McGill University;Department of Neurology and Neurosurgery, McGill University

DOI  :  10.1093/sleep/zsac136

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Restless legs syndrome (RLS) is a common neurological disordercharacterized by an urge to move the legs, particularly in theevening and at night [1]. Epidemiological studies have shown that5%–15% of European and North American populations suffer fromRLS, whereas the prevalence is lower in most Asian populations,ranging from 1% to 3% [2]. Because of its high prevalence, RLSleads to an important social and economic impact by disruptingsleep, affecting work productivity and the quality of life.

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