Abnormal rapid eye movement sleep atonia control in chronic post-traumatic stress disorder

Sleep

article

Feemster, John C¹  Steele, Tyler A¹  Palermo, Kyle P¹  Ralston, Christy L¹  Tao, Yumeng¹  Bauer, David A¹  Edgar, Liam¹  Rivera, Sonia¹  Walters-Smith, Maxwell¹  Gossard, Thomas R¹  Teigen, Luke N¹  Timm, Paul C¹  Richardson, Jarrett W¹  Robert Auger, R¹  Kolla, Bhanuprakash¹  McCarter, Stuart J¹  Boeve, Bradley F¹  Silber, Michael H¹  St. Louis, Erik K¹ 

[1] Mayo Sleep Behavior and Neurophysiology Research Laboratory, Mayo Center for Sleep Medicine, Mayo Clinic and Foundation;Division of Pulmonary and Critical Care Medicine, Mayo Clinic and Foundation;Department of Medicine, Mayo Clinic and Foundation;Department of Neurology, Mayo Clinic and Foundation;St. Olaf College;Cornell College;Department of Psychiatry, Mayo Clinic and Foundation;Mayo Clinic Health System Southwest Wisconsin

关键词: post-traumatic stress disorder;    REM sleep behavior disorder;    dream enactment behavior;    REM sleep without atonia;   

DOI  :  10.1093/sleep/zsab259

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study Objectives Post-traumatic stress disorder (PTSD) and rapid eye movement (REM) sleep behavior disorder (RBD) share some common features including prominent nightmares and sleep disturbances. We aimed to comparatively analyze REM sleep without atonia (RSWA) between patients with chronic PTSD with and without dream enactment behavior (DEB), isolated RBD (iRBD), and controls.Methods In this retrospective study, we comparatively analyzed 18 PTSD with DEB (PTSD+DEB), 18 PTSD without DEB, 15 iRBD, and 51 controls matched for age and sex. We reviewed medical records to determine PTSD clinical features and quantitatively analyzed RSWA. We used nonparametric analyses to compare clinical and polysomnographic features.Results PTSD patients, both with and without DEB, had significantly higher RSWA than controls (all p < .025, excepting submentalis phasic duration in PTSD+DEB). Most RSWA measures were also higher in PTSD+DEB than in PTSD without DEB patients (all p < .025).Conclusions PTSD patients have higher RSWA than controls, whether DEB is present or not, indicating that REM sleep atonia control is abnormal in chronic PTSD. Further prospective studies are needed to determine whether neurodegenerative risk and disease markers similar to RBD might occur in PTSD patients.

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