Histogram peritumoral enhanced features on MRI arterial phase with extracellular contrast agent can improve prediction of microvascular invasion of hepatocellular carcinoma

Quantitative Imaging in Medicine and Surgery

article

Xinxin Wang¹  Yunfeng Sun¹  Xueyan Zhou²  Zhiwei Shen³  Hongxia Zhang¹  Jiqing Xing⁴  Yang Zhou¹ 

[1] Department of Radiology , Harbin Medical University Cancer Hospital;School of Technology , Harbin University;Philips Healthcare China;Department Physical Education , Harbin Engineering University

关键词: Microvascular invasion (MVI);    hepatocellular carcinoma (HCC);    contrast enhancement;    quantitative analysis;    magnetic resonance imaging (MRI);   

DOI  :  10.21037/qims-21-499

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Background: Preoperative microvascular invasion (MVI) prediction plays an important role in therapeutic decision-making of hepatocellular carcinoma (HCC). This study aimed to investigate the value of histogram based on the arterial phase (AP) of magnetic resonance imaging (MRI) with extracellular contrast agent compared with radiological features for predicting MVI of solitary HCC. Methods: 3 cm cohort. Based on pathological analysis of surgical specimens, the patients were classified into MVI negative (MVI−) and MVI positive (MVI+) groups. Peritumoral and intratumoral histogram features [mean, median, standard deviation (Std), coefficient of variation (CV), skewness, kurtosis] were acquired on AP subtraction images and radiological features [size, capsule, corona enhancement, corona enhancement thickness (CET), CET group]. Receiver operating characteristic (ROC) curve was constructed to assess predictive capability. Subgroup analysis of patients with a visible corona enhancement based on the CET cut-off value was performed. Results: 3 cm with an area under the curve (AUC) of 0.741. Peri-mean was an independent predictor for sHCC (AUC =0.798). Subgroup analysis of the corona enhancement using 8 mm as a cut-off value showed 100% sensitivity and negative predictive value (NPV). Conclusions: Peritumoral AP enhanced degree on MRI showed an encouraging predictive performance for preoperative prediction of MVI, especially in sHCCs. CET ≤8 mm could be used as a negative predictive marker for MVI.

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