A Review On: Colon Targeted Drug Delivery System

American Journal of PharmTech Research

article

Ayushi M. Pawar¹  Swapnil R. Patil²  Tushar D. Fegade¹ 

[1] Department of Pharmacology, Arunamai college of Pharmacy, Mamurabad, KBC, North Maharashtra University;Department of Pharmaceutics, Vidya Bharati College of Pharmacy, Amravati University

关键词: Colon targeted drug delivery;    Factors affecting colon delivery;    Novel approaches;    Disease of colon-specific drug delivery systems.;   

DOI  :  10.46624/ajptr.2020.v10.i2.016

学科分类：药学

来源: American Journal Of Pharmtech Research

【 摘 要 】

Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions. Drugs such as proteins and peptides that are known to degrade in the extreme gastric pH, if delivered to the colon intact, can be systemically absorbed by colonic mucosa. In order to achieve effective therapeutic outcomes, it is imperative that the designed delivery system specifically targets the drugs into the colon. Several formulation approaches have been explored in the development colon-targeted drug delivery systems. Colon targeting holds a great potential and still need more innovative work. This review article discusses introduction of colon, need and approaches of colonic drug delivery, factor effecting colonic transition, colonic diseases and the novel and emerging technologies for colon targeting.

【 授权许可】

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