AIMS Allergy and Immunology | |
IL-17 signaling is regulated through intrinsic stability control of mRNA during inflammation | |
article | |
Ryuta Muromoto1  Kenji Oritani2  Tadashi Matsuda1  | |
[1] Department of Immunology, Graduate School of Pharmaceutical Sciences Hokkaido University;Department of Hematology, International University of Health and Welfare | |
关键词: IL-17; Th17; IκB-ζ; Regnase-1; mRNA stabilization; inflammation; | |
DOI : 10.3934/Allergy.2022014 | |
学科分类:医学(综合) | |
来源: American Institute of Mathematical Sciences | |
【 摘 要 】
Interleukin (IL)-17 is a proinflammatory cytokine mainly produced by immune cells, especially activated T-helper 17 cells, which contribute to chronic inflammatory and autoimmune diseases including psoriasis. Although the molecular mechanisms of transcription in IL-17-mediated signaling pathways are well established, post-transcriptional control remains to be elucidated. Notably, IL-17 regulates post-transcriptional modifications, which induce elevated levels of target inflammatory mRNAs. Regnase-1, an endoribonuclease and deubiquitinase, post-transcriptionally downregulates various IL-17-driven signaling pathways, including mRNA stability. The ACT1-TBK1/IKKϵ pathway and ARID5A were induced and activated by IL-17-stimulation, leading to the inhibition of inflammatory mRNA degradation by Regnase-1. In this review, we focus on IL-17-mediated mRNA stabilization of psoriasis-related IκB-ζ and provide novel therapeutic strategies for the treatment of Th17-mediated inflammation and autoimmunity.
【 授权许可】
CC BY
【 预 览 】
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RO202302200003542ZK.pdf | 765KB | download |