IL-17 signaling is regulated through intrinsic stability control of mRNA during inflammation

AIMS Allergy and Immunology

article

Ryuta Muromoto¹  Kenji Oritani²  Tadashi Matsuda¹ 

[1] Department of Immunology, Graduate School of Pharmaceutical Sciences Hokkaido University;Department of Hematology, International University of Health and Welfare

关键词: IL-17;    Th17;    IκB-ζ;    Regnase-1;    mRNA stabilization;    inflammation;   

DOI  :  10.3934/Allergy.2022014

学科分类：医学（综合）

来源: American Institute of Mathematical Sciences

【 摘 要 】

Interleukin (IL)-17 is a proinflammatory cytokine mainly produced by immune cells, especially activated T-helper 17 cells, which contribute to chronic inflammatory and autoimmune diseases including psoriasis. Although the molecular mechanisms of transcription in IL-17-mediated signaling pathways are well established, post-transcriptional control remains to be elucidated. Notably, IL-17 regulates post-transcriptional modifications, which induce elevated levels of target inflammatory mRNAs. Regnase-1, an endoribonuclease and deubiquitinase, post-transcriptionally downregulates various IL-17-driven signaling pathways, including mRNA stability. The ACT1-TBK1/IKKϵ pathway and ARID5A were induced and activated by IL-17-stimulation, leading to the inhibition of inflammatory mRNA degradation by Regnase-1. In this review, we focus on IL-17-mediated mRNA stabilization of psoriasis-related IκB-ζ and provide novel therapeutic strategies for the treatment of Th17-mediated inflammation and autoimmunity.

【 授权许可】

CC BY