In Vitro Anti-Candidial Activity of Some Iranian Medicinal Plants Against Candida Species

International Journal of Enteric Pathogens

article

Nasrin Amirrajab¹  Batool Sadeghi-Nejad²  Sedigheh Yusef Naanaie³  Sadegh Tehrani⁴  Yusef Yalaly⁴  Ehsan Ahmadi⁴ 

[1] Department of Laboratory Sciences, School of Allied Medical Sciences/Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences;Abadan University of Medical Sciences;The Agricultural and Natural of Resources Center;Student Research Committee, Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences

关键词: Anti-Candidial;    C;    albicans;    C.glabrata;    C;    tropicalis;    Medicinal plants;   

DOI  :  10.34172/ijep.2021.11

学科分类：农业科学（综合）

来源: Alborz University of Medical Sciences

【 摘 要 】

Background: Candida albicans is an organism most often associated with serious fungal infection, which has recently shown an increased resistance to commercial antifungal agents. As a result, using medicinal plants as an alternative method to address health problems has received a particular attention in developing countries. Objective: This study aimed to examine the anti-Candidial potential of the extracts from Zataria multiflora Boiss (ZMB), Stachys acerosa Boiss (SAB), Prangos ferulacea (L.) Lindl (PFL), Tanacetum parthenium L. (TAPL), Teucrium polium L. (TEPL), and Cinnamomum zeylanicum L. (CZL) against three strains of Candida , including C. albicans , C. glabrata , and C. tropicalis . Materials and Methods: To this end, several tests were performed to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) against Candida species, using the agar well diffusion method (AWDM). Results: According to our study results, the hydroethanolic extracts of six medicinal plants exhibited anti-Candidial activities. The extracts of ZMB, SAB, and CZL demonstrated strong anti-Candidial activities, while the hydroethanolic extracts of PFL, TAPL, and TEPL revealed moderate anti-Candidial activities at any of the tested concentrations. The highest inhibitory activity (ZOI: 38 mm) was recorded for the effect of CZL on C. albicans with MIC=1.56 mg/mL, and the lowest anti-Candidial one (ZOI: 8 mm) was documented for the effect of T. parthenium on C. albicans with minimum inhibitory concentration (MIC)=50 mg/mL. Conclusion: The ascending sequence of fungicidal growth inhibition zones was as follows: C. zeylanicum > Z. multiflora > S. acerosa > T. polium > T. parthenium and P. ferulacea .

【 授权许可】

CC BY-NC