Is there a relationship between vitamin D levels, inflammatory parameters, and clinical severity of COVID-19 infection?

Bratislava Medical Journal

article

Gulcan OZTURK¹  Berrin Zinnet ERASLAN²  Pinar AKPINAR¹  Duygu KARAMANLIOGLU SILTE¹  Feyza OZKAN UNLU¹  Ilknur AKTAS¹ 

[1] University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital;University of Health Sciences Kartal Lütfi Kirdar Education and Training Hospital

关键词: COVID-19 pandemic;    severity of illness;    inflammation;    vitamin D;   

DOI  :  10.4149/BLL_2022_065

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

OBJECTIVES: This study is aimed to determine the relationship between 25-OH vitamin D levels, inflammatory parameters of neutrophil‑to‑lymphocyte ratio (NLR), platelet‑to‑lymphocyte ratio (PLR), c‑reactive protein (CRP) levels and the disease severity of COVID-19 infection. BACKGROUND: Inflammation plays a key role in the pathogenesis of COVID-19 while identifying the clinical course and prognosis. The effect of vitamin D deficiency on contribution to inflammation in COVID-19 is unclear. METHODS: Based on the classification of the clinical course of COVID-19, the patients were divided into three groups, i.e., with mild (Group 1), moderate (Group 2) and severe/critical cases (Group 3). The 25-OH vitamin D values were defined as deficient, insufficient or normal. RESULTS: There were no statistically significant differences in the distribution rates of 25-OH vitamin D levels (p>0.05) between the groups. Inflammatory parameters in Group 3 were statistically significantly higher as compared to Groups1 and 2 (p<0.05). Multivariate logistic regression analysis revealed that NLR was an independent predictor of disease severity. CONCLUSION: There is no relationship between the severity of COVID-19 infection and 25-OH vitamin D deficiency. Inflammatory parameters are associated with the disease severity, while NLR is an independent predictor of severe COVID-19. There was no correlation between 25-OH vitamin D and inflammatory markers (Tab. 4, Fig. 1, Ref. 38).

【 授权许可】

CC BY