Screening diagnosis of dementia in patients following heart failure decompensation is associated with a higher relative wall thickness

Bratislava Medical Journal

article

Karol NOWAK¹  Adam STEPIEN¹  Patrycja FURCZYNSKA¹  Magdalena ZALEWSKA²  Gabriela KANCLERZ¹  Alicia del Carmen YIKA¹  Konrad STEPIEN¹  Jadwiga NESSLER¹  Jaroslaw ZALEWSKI¹ 

[1] Department of Coronary Artery Disease and Heart Failure, Jagiellonian University Medical College;Department of Emergency Medicine, Faculty of Health Sciences, Jagiellonian University Medical College;Department of Coronary Artery Disease and Heart Failure, John Paul II Hospital;Club 30”, Polish Cardiac Society;Department of Coronary Artery Disease and Heart Failure, John Paul II Hospital, Krakow, Poland, and 4 “Club 30”, Polish Cardiac Society

关键词: dementia;    heart failure;    decompensation;    echocardiography;    relative wall thickness;   

DOI  :  10.4149/BLL_2022_109

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

BACKGROUND: The usefulness of echocardiographic characteristics for dementia prediction in patients with heart failure decompensation (HFD) is not determined. Therefore, we sought to investigate the echocardiographic features of patients with HFD and screening diagnosis of dementia (SDD). METHODS: 139 patients aged over 65 years were hospitalized with the diagnosis of HFD. Clinical characteristics and echocardiographic characteristics were recorded during hospitalization. SDD was defined based on the result of ALFI– MMSE of <17 points. RESULTS: Patients with SDD were older (p=0.013), had thicker IVSd (p=0.021), thicker PWd (p=0.005) and had a higher RWT (0.40 vs 0.35, p=0.004) than patients without SDD, without differences in LVMI (p=0.13). There was no correlation between RWT and LVMI (r=−0.01, p=0.88). In the multivariate analysis, an older age (β=−0.116, 95% CI −0.224 – −0.008, p=0.035, per year) and a higher RWT (β=−0.069, 95% CI −0.137 – −0.002, p=0.045, per 0.01) influenced a lower ALFI-MMSE. For a prediction of SDD, the RWT reached the area under a ROC curve of 0.67 (95% CI 0.56–0.77, p=0.004 with sensitivity of 60% and specificity of 70% for RWT of ≥0.375). CONCLUSIONS: Apart from age, RWT reflecting left ventricular geometry changes but not hypertrophy was independently but moderately associated with SDD in patients following HFD (Tab. 4, Fig. 1, Ref. 35).

【 授权许可】

CC BY