Bilateral testicular germ cell tumors – 50 years experience

Bratislava Medical Journal

article

B. Mrinakova¹  B. Trebaticky²  K. Kajo³  M. Ondrusova⁴  V. Lehotska⁵  I. Waczulikova⁶  D. Ondrus¹ 

[1] 1st Department of Oncology, Comenius University Faculty of Medicine & St. Elisabeth, Cancer Institute;Department of Urology, Comenius University Faculty of Medicine & University Hospital;Department of Pathology, Slovak Medical University & St. Elisabeth Cancer Institute;Pharm-In, Ltd.;2nd Department of Radiology, Comenius University, Faculty of Medicine & St. Elisabeth, Cancer Institute;Department of Nuclear Physics and Biophysics, Division of Biomedical Physics, Comenius University, Faculty of Mathematics

关键词: bilateral testicular cancer;    interval;    synchronous;    metachronous tumours;    seminoma;    nonseminoma;    discordant;   

DOI  :  10.4149/BLL_2021_074

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

OBJECTIVE: This study analysed the characteristics and outcome of the patients with bilateral germ testicular cell cancer (TC), especially synchronous. METHODS: Among 2.124 TC patients diagnosed between 1970 and 2020, 96 (4. 5%) developed the 2nd TC. Nine occurred synchronously and 87 were metachronous. Patients were analysed according to the age and histological type of bilateral TC in comparison with unilateral TC. RESULTS: The mean follow-up of all 2,124 patients was 14.9 years. Unilateral TC occurred in 2.028 patients (the mean age of 32.4 years), 707 of them had seminoma, 1.310 nonseminomatous (NS) TC and 11 spermatocytic tumours. The 1st tumour of metachronous bilateral disease was diagnosed at a significantly younger age (27.1 years) compared to the unilateral disease (32.4 years). The mean interval between the 1st and the 2nd TC was 8.2 years. Patients with NSTC had a longer mean interval (9.2 years) between the 1st and the 2nd TC in comparison with seminoma patients (6.7 years). The mean age at diagnosis for seminoma was significantly higher (31.3 years) compared to the NSTC (24.1 years). Bilateral seminoma occurred in 5 synchronous bilateral TC patients, four patients had discordant histology, none presented with bilateral NSTC. CONCLUSIONS: Bilateral TC is a rare and requires individualized management of patients (Tab. 5, Fig. 4, Ref. 32).

【 授权许可】

CC BY