Effects of serum vitamin D level on ventricular repolarization in children and adolescents

Bratislava Medical Journal

article

M. Bekdas¹  M. Inanir²  Z. Ilhan¹  E. Ildes¹ 

[1] Department of Pediatrics, Bolu Abant Izzet Baysal Univ ersity Faculty of Medicine;Department of Cardiology, Bolu Abant Izzet Baysal University Faculty of Medicine

关键词: adolescent;    arrhythmia;    child;    vitamin D;    ventricular repolarization;   

DOI  :  10.4149/BLL_2021_130

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

OBJECTIVES: Low levels of vitamin D are known to increase cardiovascular mortality due to different risks. We aimed to examine whether low vitamin D levels in children and adolescents cause ventricular repolarization changes. METHODS: Sixtyseven healthy cases aged between 3.5 and 17 years were included. According to levels of vitamin D, cases were grouped as sufficient (n=44), insufficient (n=13) and deficiency (n=10). Ventricular repolarization parameters were measured manually. RESULTS: Levels of vitamin D were different for cases with insufficiency and deficiency compared to sufficiency ones (102±54.9 vs 24.4±7 ng/ml, p<0.001 and 102±54.9 vs 16.6±8.3 ng/ml, respectively, p<0.001). In the insufficient group the following parameters were different from sufficient group: QTmean (357.8±25.3 vs 332±29.9 ms, p=0.012), JTc (310.8±20.2 vs 331.6±21 ms, p=0.005) and Tpe/QT (0.2±0.02 vs 0.22±0.02, p=0.02). It was found that the level of serum vitamin D correlated with JTc (r=–0.37, p=0.002), Tp-e (r=–0.29, p=0.015) and Tp-e/QT (r=–0.24, p=0.047). In the linear regression analysis, it was found that dropping level of vitamin D below normal was an independent risk factor for prolonged duration of JTc (p=0.015). CONCLUSIONS: Decline in vitamin D levels causes ventricular repolarization anomaly. As the decrease in vitamin D levels deepens, repolarization times become longer. These results could indicate that decrease in vitamin D levels can increase sensitivity to ventricular arrhythmias.

【 授权许可】

CC BY