Non-alcoholic fatty liver disease increases the prevalence of maintenance haemodialysis in patients with chronic kidney disease

Bratislava Medical Journal

article

Y. C. Lu¹  C. Y. Hsu² 

[1] Department of Internal Medicine, National Taiwan University Hospital;Department of Family Medicine, Puli Christian Hospital;Department of Medical Education and Research, Puli Christian Hospital;Department of Optometry, Central Taiwan University of Science and Technology;Center for General Education, National Taichung University of Science and Technology;The General Education Center, Chaoyang University of Technology;Department of General Education, National Chin-Yi University of Technology;Center for General Education, Feng Chia University;Center for General Education, National Chi Nan University;Rural Generalist Program Japan

关键词: non-alcoholic fatty liver disease;    haemodialysis;    chronic kidney disease;    proteinuria;   

DOI  :  10.4149/BLL_2020_055

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

AIM: To investigate the association between non-alcoholic fatty liver disease (NAFLD) and incidence of maintenance haemodialysis in patients with chronic kidney disease (CKD). METHODS: We enrolled patients diagnosed with CKD between 2001 and 2007. The patients were categorized into two groups based on abdominal ultrasound finding, namely those with NAFLD and those without NAFLD. The disease (maintenance haemodialysis)-free survival rate was estimated using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses was used to evaluate the hazard ratios of covariates for the incidence of maintenance haemodialysis. RESULTS: A total of 161 patients (61 with NAFLD and 100 without NAFLD) were enrolled. The mean age was 69.3 years. The mean follow-up was 7.4 years. The patients with NAFLD had an increased incidence of maintenance haemodialysis (39.3 % vs 24.0 %; p=0.0396) and inferior disease-free survival rate (p=0.006). Furthermore, diabetes (p=0.0126) and proteinuria (p=0.0003) were identified as significant predictors of CKD progression. CONCLUSION: NAFLD was associated with an increased incidence of maintenance haemodialysis and inferior disease-free survival rate. NAFLD may impair renal function and patients with renal impairment should be monitored carefully.

【 授权许可】

CC BY