Effect of the nervous system on cancer: Analysis of clinical studies

Bratislava Medical Journal

article

B. Mravec¹  J. Dubravicky³  M. Tibensky¹  L. Horvathova² 

[1] Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava;Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences;Department of Urology, University Hospital

关键词: cancer;    neurobiology of cancer;    norepinephrine;    sympathetic nervous system;    spinal cord injury;    pheochromocytoma;   

DOI  :  10.4149/BLL_2019_019

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

Preclinical data have shown that neurotransmitters released in peripheral tissues from nerve endings may influence carcinogenesis, affect the tumor microenvironment, and directly potentiate both proliferation and migration of cancer cells. This stimulatory role of the nervous system in cancer initiation and progression has also been documented by clinical studies investigating the effect of attenuated signaling from nerves innervating cancer tissue. However, compared to preclinical studies, clinical studies are rarer and some of them have ambiguous results. In this retrospective analysis, to assess the effect of the nervous system on cancer, we analyzed published clinical studies investigating the incidence of cancer in patients with spinal cord injury or pheochromocytoma. Our findings support a concept of the neurobiology of cancer based on the assumption that the nervous system affects cancer initiation and progression (Ref. 60).

【 授权许可】

CC BY