Atherosclerosis in cancer patients

Bratislava Medical Journal

article

B. Mladosievicova¹  L. Petrikova¹  Z. Valaskova¹  M. Bernadic Jr³  M. Chovanec⁴  M. Mego⁴  M. Bernadic Sr¹ 

[1] Institute of Pathological Physiology, Faculty of Medicine, Comenius University;Department of Oncohematology, Comenius University in Bratislava and National Cancer Institute;Department of Surgical Oncology, National Cancer Institute Bratislava;2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute;Translational Research Unit at 2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute

关键词: cardiovascular disease;    atherosclerosis;    cardiotoxicity;    risk factors;    hypertension;    hyperlipidemia;   

DOI  :  10.4149/BLL_2019_105

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

Cancer-related mortality have been declining in the last decades. Approximately half of adults and more than two thirds of children oncological patients live longer than 5 years after diagnosis. However, this optimistic scenario has been counterbalanced by an increasing cardiovascular risk in cancer patients. Atherosclerotic damage has been underestimated in oncology practice for a long time, but recently a significant number of cancer patients with cardiovascular risk factors and serious artery disease during and after anticancer therapy has been reported. Complexity of atherosclerosis in cancer patients is challenging. Herein, we describe cardiovascular risk factors and pathophysiological mechanisms of atherosclerosis induced by selected classic chemotherapeutics, targeted cancer therapies, hormonal agents and radiotherapy and new clinical data regarding atherosclerosis, which received a particular attention in recent years (Tab. 1, Ref. 26).

【 授权许可】

CC BY