Lycopene has a protective effect on septic shock‑induced cardiac injury in rats

Bratislava Medical Journal

article

I. V. Duzen¹  E. Oguz²  R. Yilmaz³  A. Taskin⁴  E. Vuruskan¹  Y. Cekici⁵  Z. G. Bilgel⁶  H. Goksuluk⁷  B. Candemir⁷  M. Sucu¹ 

[1] Department of Cardiology, Faculty Of Medicine Gaziantep University;Department of Pharmacology, Faculty of Medicine, Medeniyet University;Department of Pathology, Faculty of Veterinary Science, Harran University;Department of Biochemistry, Faculty of Health Sciences, Harran University;Cardiology Clinic Dr Ersin Arslan Education and Research Hospital.Gaziantep;Cardiology Clinic 25 Aralik State Hospital;Department of Cardiology, Faculty of Medicine, Ankara Univeristy

关键词: lycopene;    sepsis;    antioxidant;    anti-inflammatory;   

DOI  :  10.4149/BLL_2019_154

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

OBJECTIVE: The aim of the present study is to investigate the cardioprotective effect of lycopene, known for its antioxidant and anti-inflammatory effect, in a rat sepsis model induced by lypopolysaccharide (LPS). METHODS: The oxidative stress parameters, antioxidant parameters and cytokine levels with or without lycopene treatment in LPS‑induced septic rats as well as in controls were measured in serum and tissue. Histologic examinations of the cardiac tissues were also performed. The Kruskal–Wallis and the Bonferroni-adjusted Mann–Whitney U Test was used for analysis. A p value < 0.05 was considered significant. RESULTS: The data of this study showed that lycopene pretreatment reduced the oxidative stres parametersand , proinflammatory cytokines as well as increased the antoxidant enzyme activities in both serum and cardiac tissues in LPS‑induced septic rats.. Moreover, hyperaemia and haemorrhage in the epicardium, myocardium and endocardium were lower in the lycopene pretreated group as compared to the LPS alone group. CONCLUSION: These results suggest that lycopene could be beneficial for the prevention of cardiac injury caused by sepsis through reducing the cytokine levels and oxidative stress parameters (Tab. 4, Fig. 1, Ref. 35).

【 授权许可】

CC BY