Evaluation of pentraxin-3 in familial Mediterranean fever patients during attack and attack-free periods

Bratislava Medical Journal

article

M. Gok¹  O. Sirkeci²  M. Kara³  Y. S. Sakin⁴  A. Tanoglu³  E. E. Sirkeci⁵  H. Oztin⁶  T. Duzenli³  M. Kaplan³  Y. Yazgan³  O. M. Ipcioglu⁷ 

[1] Department of Internal Medicine, Sultan Abdulhamid Han Training and Research Hospital;Department of Internal Medicine, Near East University Hospital;Department of Gastroenterology, Sultan Abdulhamid Han Training and Research Hospital;Department of Gastroenterology, Gulhane Training and Research Hospital;Department of Emergency Medicine, Near East University Hospital;Department of Geriatrics, Gulhane Training and Research Hospital;Department of Biochemistry, Sultan Abdulhamid Han Training and Research Hospital

关键词: familial Mediterranean fever;    pentraxin-3;    inflammation;   

DOI  :  10.4149/BLL_2018_089

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

INTRODUCTION: Pentraxin-3 (PTX-3) is a prototype of pentraxin proteins that have been shown to be involved in acute phase response. In this study, we aimed to investigate the relationship between PTX-3 levels and familial Mediterranean fever (FMF) disease, and to evaluate PTX-3 as a novel diagnostic marker of FMF. METHOD: Forty-three male patients diagnosed with FMF and 42 healthy individuals were included in the study. Patients with other inflammatory diseases and patients who used drugs having anti-inflammatory properties were excluded from the research. Blood samples were obtained during both attack and attack-free periods. RESULTS: Patient attack periods were confirmed by combining physical examination and elevation of acute phase reactants. Acute phase reactants were significantly higher in attack versus attack-free periods (p < 0.01), however PTX-3 levels were not significantly different between the two periods. Additionally, PTX-3 levels in FMF patients were higher than in controls in both attack (917.29 ± 725.29 vs 451.83 ± 291.95, p < 0.01) and attack-free periods (748.23 ± 487.53 vs 451.83 ± 291.95, p < 0.01). CONCLUSION: In this study, we showed that PTX-3 levels, in both FMF attack and attack-free periods, were significantly higher than in the control group. Finally, PTX-3 may be a promising biomarker for FMF diagnosis and may predict FMF attacks (Tab. 2, Fig. 2, Ref. 18).

【 授权许可】

CC BY