Molecular Infection in Tumor Growth Through Hypoxic Disorder

Journal of applied sciences research

article

Iman Mostafa¹ 

[1] Islamic Shiraz University, School of Veterinary Medicine

关键词: Molecular Infection;    Hypoxic;    Oxygen Modelling;    Tumor Growth;   

DOI  :  10.22587/jasr.2019.15.4.4

学科分类：社会科学、人文和艺术（综合）

来源: AENSI

【 摘 要 】

Hypoxia is a situation in which the body or part of the body is excluded of sufficient oxygen at the tissue level. And the Double-Stranded RNA virus is a powerful oncolytic virus, which is especially replicated in tumor cells and kills their result, called mammalian virus (MRV). This article investigates the ability of MRV to infect hypoxic tumor cells. This article showed that not only do they successfully translate proteins and replicate in hypoxic tumor cells, they also induce apoptosis. The paper also simplifies the involvement of any MRV protein in inhibiting HIF-1α and obtaining μ1 and μ2 proteins capable of freely resetting HIF-1α. Prostate cancer interdependence (PCA) on androgens for growth and survival is elicited by hormone therapy, in which androgen deprivation is used as an appropriate treatment. However, initially successful, this androgenrelated PCA progresses to androgen-independent PCA, where hypoxia has been shown to play a critical role. The present study also investigated the effect of MRV infection on androgen-dependent hypoxic LNCaP cells. The results prove that MRV promotes apoptosis in hypoxic and normoxic LNCaP cells as well as activates Akt reality and does not regulate prostate-specific antigen (PSA).

【 授权许可】

Unknown