Role of RNA-binding proteins in both COPD and lung cancer

Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche

article

Francesco Monaco¹  Antonio Ieni²  Guido Fadda²  Giovanni Tuccari²  Cristiana Stellato³  Gaetano Caramori⁴  Francesco Nucera⁴  Ilaria Salvato⁴  Luca Ricciardi⁴  Annunziata Nigro³  Jessica Dal Col³ 

[1] Chirurgia Toracica, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali ,(BIOMORF), Università degli Studi di Messina;Department of Human Pathology of Adult and Developmental Age "Gaetano Barresi", Section of Pathological Anatomy, University of Messina;Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno;Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali ,(BIOMORF), Università degli Studi di Messina

关键词: chronic airway inflammation;    COPD;    lung cancer;    post-transcriptional regulation;    RNA-binding proteins;   

DOI  :  10.13129/1828-6550/APMB.110.2.2022.SD1

学科分类：农业科学（综合）

来源: Accademia Peloritana dei Pericolanti

【 摘 要 】

Chronic obstructive pulmonary disease (COPD) is an independent risk factor for the development of lung cancer. Several pathogenic pathways such as oxidative stress and chronic inflammation of the lower airways are shared by these two diseases. The RNA-binding proteins (RBPs) can modulate the post-transcriptional expression of genes involved in several biological processes, such as cell cycle, cell proliferation and injury/stress responses. The bonding between RBPs and targeted transcripts regulates mRNA turnover, subcellular localization, splicing and translation, through the formation of ribonucleoproteins (RNPs) complexes. Several pro-inflammatory mediators, that induce and maintain chronic lung inflammation and carcinogenesis, are modulate by RBPs. RBPs can have a key role in lung cancer onset in COPD patients, sharing several common pathogenic processes, including oxidative stress, inflammation of lower airways, DNA damage and impaired DNA-repair mechanisms. Further studies are mandatory to clarify the application of RBPs as novel biomarkers and potential therapeutic targets. This review will investigate recent evidences showing the role of RBPs in the pathogenic mechanisms sharing by lung cancer and COPD.

【 授权许可】

CC BY