A rare case of sphenoid giant cell tumor: Case report & review of imaging features post short-term denosumab treatment

Radiology Case Reports

article

Farid Aassouani¹  Nizar El Bouardi¹  Yahya Charifi¹  Kaoutar Maadin¹  Amina Bouziane¹  Meryem Haloua¹  Moulay Youssef Alaoui Lamrani¹  Samia Arifi¹  Touria Bouhafa¹  Meriem Boubbou¹  Mustapha Maaroufi¹  Badreeddine Alami¹ 

[1] Department of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University

关键词: Giant cell tumor;    Sphenoid;    Denosumab;   

DOI  :  10.1016/j.radcr.2022.07.040

学科分类：生物化学工程

来源: University of Washington * Department of Radiology

【 摘 要 】

Background: Giant cell tumors (GCTs) are locally aggressive but rarely malignant bone neoplasms that uncommonly involve the skull. In this report, we describe a tumor of the sphenoid sinus . Case presentation: A 51-year-old female was presented with headache, and bilateral decreased visual acuity , CT scan , and brain MRI revealed an infra-sellar enhancing tumor expanding to the sellar and supra-sellar region which proved to be a GCT. the patient had received 03 months of preoperative denosumab-based treatment and imaging follow-up showed regression in size and morphology modifications of tumor tissue. Conclusion : This is one of few reports to describe the appearance of sphenoid bone GCT , and the first report to highlight the effects of short-term denosumab treatment in GCTb in such a location.

【 授权许可】

CC BY|CC BY-NC-ND