An unusual case of hepatosplenic T-cell lymphoma-like unclassifiable T/NK-cell lymphoma accompanied by acute myeloid leukemia

eJHaem

article

Shin Lee¹  Yusuke Kito²  Kei Fujita¹  Hiroto Wakayama¹  Masaki Kimura³  Keisuke Kawashima²  Tetsuya Tabata⁴  Tadashi Yoshino⁴  Takeshi Hara¹  Hisashi Tsurumi¹ 

[1] Department of Hematology and Oncology, Matsunami General Hospital;Department of Pathology, Matsunami General Hospital;Department of Gastrointestinal Surgery, Matsunami General Hospital;Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

关键词: acute myeloid leukemia;    CD56;    hepatosplenic T-cell lymphoma;    splenomegaly;    TCR rearrangement;   

DOI  :  10.1002/jha2.565

来源: Wiley

【 摘 要 】

We describe a case of unclassifiable T/NK-cell lymphoma with concomitant acute myeloid leukemia (AML). A 73-year-old Japanese man was diagnosed with AML by bone marrow smear, but the presence of splenomegaly and liver tumor was incompatible with AML. Splenectomy and hepatic resection were performed to resolve the thrombocytopenia and define the diagnosis. The pathological findings showed sinusoidal involvement of abnormal lymphoid cells that were CD3-positive but negative for T-cell receptor (TCR) rearrangement. Our case could not be categorized as hepatosplenic T-cell lymphoma because of the lack of immunohistological expression of TCR, despite the clinical similarity.

【 授权许可】

Unknown