Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arising in the setting of polycythemia vera (PV): An illustration of the emerging role of flow cytometry analysis in monitoring progression of myeloproliferative neoplasms

eJHaem

article

Siba El Hussein¹  Mariko Yabe²  Wei Wang³  Naveen Pemmaraju⁴  Sanam Loghavi³  Fatima Zahra Jelloul³  Hong Fang³  L. Jeffrey Medeiros³  W. Richard Burack¹  Andrew G. Evans¹  Jane L. Liesveld⁵  John M. Bennett¹ 

[1]Department of Pathology, University of Rochester Medical Center

[2]Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center

[3]Department of Hematopathology, The University of Texas MD Anderson Cancer Center

[4]Department of Leukemia, The University of Texas MD Anderson Cancer Center

[5]Department of Medicine & The Wilmot Cancer Institute, University of Rochester Medical Center

关键词: blastic plasmacytoid dendritic cell neoplasm;    myeloproliferative neoplasm;    polycythemia vera;   

DOI  :  10.1002/jha2.525

来源: Wiley

【 摘 要 】

This report highlights the value of flow cytometry analysis, particularly in the setting of myeloproliferative neoplasms showing features of progression, as neoplastic plasmacytoid dendritic cell (PDC) proliferations may be present, representing either a clonal expansion of mature PDCs related to the underlying myeloproliferative neoplasm or transformation to blastic plasmacytoid dendritic cell neoplasm (BPDCN). BPDCN should always be considered in patients with myeloid neoplasms in progression and/or who develop new cutaneous findings, as it may prompt change of management.

【 授权许可】

Unknown