Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma

eJHaem

article

Esther E. E. Drees¹  Julia Driessen²  Gerben J. C. Zwezerijnen²  Sandra A. W. M. Verkuijlen¹  Jakoba J. Eertink²  Monique A. J. van Eijndhoven¹  Nils J. Groenewegen¹  Andrea Vallés-Martí¹  Daphne de Jong¹  Ronald Boellaard²  Henrica C. W. de Vet²  Dirk M. Pegtel¹  Josée M. Zijlstra¹ 

[1]Amsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Pathology

[2]Cancer Center Amsterdam

[3]Amsterdam UMC, location University of Amsterdam, Department of Hematology, LYMMCARE ,(Lymphoma and Myeloma Center)

[4]Amsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Radiology and Nuclear Medicine

[5]Amsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Hematology

[6]Exbiome B.V.

[7]Amsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health research institute

关键词: extracellular vesicles;    FDG-PET;    Hodgkin lymphoma;    miRNAs;    Radiomics;    TARC;   

DOI  :  10.1002/jha2.432

来源: Wiley

【 摘 要 】

Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative 18 F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.

【 授权许可】

Unknown