Lymphoplasmacytic variant of multiple myeloma

eJHaem

article

Silje Johansen¹  Hilde Kollsete Gjelberg²  Håkon Reikvam¹ 

[1] Department of Medicine, Haukeland University Hospital;Department of Pathology, Haukeland University Hospital;Department of Clinical Science, University of Bergen

关键词: Lymphoproliferative disease- multiple myeloma;   

DOI  :  10.1002/jha2.437

来源: Wiley

【 摘 要 】

A 63-year-old previously healthy male was admitted to hospital withan intense cervical backpain. Magnetic resonance imaging (MRI) scanrevealed osteolytic destruction and pathological fracture of vertebraeT1, and a low-dose computer tomography scan showed no other signof skeletal lesions. A weak monoclonal component, IgA, and increasedkappa light chain to 82.4 mg/L (reference: 6.7–22.4) were detectedin the patient’s serum, and a bone marrow biopsy was performed.The results of histopathological examination of the bone marrow areshown in Figure 1. Hematoxylin-eosin staining shows an expansion ofcells, approximately 20%, with morphology similar to mature plasmacells admixed with smaller cells with scant cytoplasm, which thusshowed more lymphoid morphology (A). The cells stained stronglypositive for both plasma cell marker CD138 (B) and B-cell markerCD20 (C), and were negative for CD45 (D) and PAX5. Kappa-lambdastaining showed kappa restriction (E). Noteworthy, cyclin D1 wasstrongly positive (F). Flow cytometry of the bone marrow showedfollowing immunophenotype CD45 weak/38+/138+/19–/20+/56weak and kappa intracellular light chains +. There were no otherclinical myeloma features at diagnosis.

【 授权许可】

Unknown