Osteolytic lesion in polycythemia vera: First report and review of literature

eJHaem

article

Verna Cheung¹  James England¹  Dawn Maze¹  Hassan Sibai¹ 

[1] Princess Margaret Cancer Centre, University of Health Network;Faculty of Nursing, University of Toronto;Department of Medicine, University of Toronto

关键词: bone pain;    myeloproliferative neoplasms (MPNs);    osteolytic lesion;    polycythemia vera;   

DOI  :  10.1002/jha2.420

来源: Wiley

【 摘 要 】

Myeloproliferative neoplasms (MPNs) are a group of rare clonal disorders of hematopoietic progenitor cells that are associated with morbidity from disease-related symptoms, thrombotic events, and risk oftransformation to acute myeloid leukemia (AML) [1]. The three mostcommon MPNs are polycythemia vera (PV), essential thrombocytosis(ET), and myelofibrosis (MF). Patients with MPN can experience a constellation of debilitating symptoms that negatively impact their qualityof life [2–5]. In prior surveys of patients with MPNs, bone pain was thefourth most common symptom reported by 44% of patients and ratedas “very severe” in up to a third of MF patients [2–5].In very rare situations, patients with MPN can develop osteolyticlesions [6–21]. We report the first case of an osteolytic lesion in achronic-phase PV patient, and review published case reports of MPNpatients with osteolytic lesions to summarize the clinical characteristics and implications for patient care.

【 授权许可】

Unknown