Primary central nervous system lymphoma: Inter-compartmental progression

eJHaem

article

Vishal Raval¹  Elaine Binkley²  Mary E. Aronow³  Juan Valenzuela⁴  David M. Peereboom⁵  Wei Wei⁶  Sunil Srivastava¹  Jaqueline Davanzo¹  Herbert Culver Boldt²  Mark P. McGarrey³  George N. Papaliodis³  Lucia Sobrin³  Ivana K. Kim³  Dimitrios G. Vavvas³  Dean Eliott³  Lakshmi Nayak⁷  Emilio Dodds⁴  Francisco Marco del Pont⁸  Arun D. Singh¹ 

[1] Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic;Department of Ophthalmology and Visual Sciences, University of Iowa;Retina Service, Massachusetts Eye and Ear, Harvard Medical School;Department of Retina and Ophthalmic Oncology;The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic;Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic;Center for Neuro-Oncology, Dana-Farber Cancer Institute;Department of neurosurgery

关键词: inter-compartment;    primary central nervous system lymphoma;    primary central nervous system lymphoma-ocular variant;    primary vitreoretinal lymphoma;    progression;    treatment;   

DOI  :  10.1002/jha2.303

来源: Wiley

【 摘 要 】

There is limited understanding of the inter-compartmental progression and treatment outcomes of primary central nervous system lymphoma (PCNSL). In this multicenter retrospective cohort study on 234 patients with PCNSL (median age: 62.5 years [18–92]; median follow-up 35 months [0.1–237.0]) from 2000 till 2018 were divided into group 1 (ocular, 44 patients): 1A and 1B without and with CNS progression and group 2 (CNS, 190 patients): 2A and 2B without and with ocular progression, respectively. In group 1 (44 patients), 33 patients received local treatment, and 11 patients received systemic treatment. In group 2 (15 patients), six patients received combination treatment, while seven patients received only systemic treatment. A complete response was observed in 19 (43%) and 91 (48%) patients in groups 1 and 2, respectively. The 2-year progression-free survival (PFS) was 35% (95% CI: 0.23, 0.54) and 56% (95% CI: 0.49, 0.63) for groups 1 and 2, respectively ( p  < 0.0001). Age < 60 years was significantly associated with longer PFS (median PFS 48 vs. 24 months, p  = 0.01). The overall survival (OS) at 2-year was similar among groups 1 and 2 (83% and 67%), respectively ( p  = 0.06). Thus, Initial compartment of involvement does not influence local response rate or OS.

【 授权许可】

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