Donor-derived lymphoma harboring a mosaic sex chromosome in a female stem cell transplantation recipient from a male sibling

eJHaem

article

Osamu Imataki¹  Hiroyuki Kubo¹  Jun-ichiro Kida¹  Makiko Uemura¹  Haruyuki Fujita¹  Norimitsu Kadowaki¹ 

[1] Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University

关键词: bone marrow transplantation;    chimerism analysis;    chromosomal abnormality;    stem cell transplantation;   

DOI  :  10.1002/jha2.347

来源: Wiley

【 摘 要 】

We treated a 68-year-old woman with malignant lymphoma. Shewas diagnosed with chronic myeloid leukemia (CML) at the age of 49years and had undergone stem cell transplantation (SCT). The donorwas the patient’s 50-year-old brother who was healthy at the time ofhis donation. Human leukocyte antigen loci 8/8 matching confirmedthat he was a compatible donor. Before SCT, the patient received areduced-intensity regimen of 30 mg/m2 fludarabine for 5 days and3.2 mg/kg IV busulfan for 4 days. The patient did not experience neither acute nor chronic graft-versus-host-disease after transplantation.There was neutrophil recovery on day 23, ascertaining engraftment.Epstein–Barr virus (EBV) antibody status was EB-VCA IgG × 160, EBVCA IgM × 10, and EBNA× 10, before SCT (70 days prior to SCT). AfterSCT (day 31), there was recovery of EBV antibody status: EB-VCA IgG× 320, EB-VCA IgM × 10, and EBNA × 20. She has been on remissionfrom CML for 19 years.

【 授权许可】

Unknown