eJHaem | |
Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single-unit cord blood transplantation in adults | |
article | |
Takaaki Konuma1  Maki Monna-Oiwa1  Kosuke Takano1  Masamichi Isobe1  Seiko Kato1  Satoshi Takahashi1  Yasuhito Nannya1  | |
[1] Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo;Division of Clinical Precision Research Platform, The Institute of Medical Science, The University of Tokyo | |
关键词: absolute lymphocyte count; allogeneic hematopoietic cell transplantation; cord blood transplantation; immune reconstitution; non-relapse mortality; survival; | |
DOI : 10.1002/jha2.372 | |
来源: Wiley | |
【 摘 要 】
We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single-unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60 days on transplant outcomes. Multivariate analysis showed that only ALC ≥300/μl at 60 days was significantly associated with overall mortality (hazard ratio, 0.24; p = 0.001) following CBT. The optimal time point to use ALC recovery as a prognostic tool following CBT could be later than those following adult donor transplantation.
【 授权许可】
Unknown
【 预 览 】
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RO202302050005728ZK.pdf | 1059KB | download |