Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single-unit cord blood transplantation in adults

eJHaem

article

Takaaki Konuma¹  Maki Monna-Oiwa¹  Kosuke Takano¹  Masamichi Isobe¹  Seiko Kato¹  Satoshi Takahashi¹  Yasuhito Nannya¹ 

[1] Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo;Division of Clinical Precision Research Platform, The Institute of Medical Science, The University of Tokyo

关键词: absolute lymphocyte count;    allogeneic hematopoietic cell transplantation;    cord blood transplantation;    immune reconstitution;    non-relapse mortality;    survival;   

DOI  :  10.1002/jha2.372

来源: Wiley

【 摘 要 】

We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single-unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60 days on transplant outcomes. Multivariate analysis showed that only ALC ≥300/μl at 60 days was significantly associated with overall mortality (hazard ratio, 0.24; p  = 0.001) following CBT. The optimal time point to use ALC recovery as a prognostic tool following CBT could be later than those following adult donor transplantation.

【 授权许可】

Unknown