Hydroxycarbamide-related cutaneous ulcer complicated by osteomyelitis

eJHaem

article

James T. England¹  Vikas Gupta¹ 

[1] Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre

DOI  :  10.1002/jha2.309

来源: Wiley

【 摘 要 】

A 78-year-old male with a history of polycythemia vera (PV) presentedwith bilateral foot ulcerations (a) limiting his ability to exercise or wearshoes. His PV had been managed for the previous 5 years with aspirin81 mg per os (PO) daily, intermittent phlebotomy, and hydroxycarbamide (hydroxyurea [HU]) 1500 mg PO daily. At the time of presentation, his hemoglobin was 138 g/L, hematocrit 0.41, white blood cellcount 14.5 × 109/L, and platelet count 695 × 1012/L. Cultures fromthe right toe ulcer grew Pseudomonas aeruginosa and Streptococcus pyogenes; scintigraphy bone scan demonstrated evidence of osteomyelitisof the right first phalanx. The HU was held and the patient was startedon a 6-week course of ciprofloxacin and doxycycline. Ruxolitinib 10 mgPO BID was initiated for management of PV. Follow-up 3 months later demonstrated significant improvement of the cutaneousulcerations (b).

【 授权许可】

Unknown