Cytopenia associated with copper deficiency

eJHaem

article

Kaori Uchino¹  Lam Vu Quang¹  Megumi Enomoto³  Yuta Nakano¹  Saki Yamada¹  Saori Matsumura¹  Jo Kanasugi¹  Soichi Takasugi¹  Ayano Nakamura¹  Tomohiro Horio¹  Satsuki Murakami¹  Mineaki Goto¹  Shohei Mizuno¹  Hidesuke Yamamoto¹  Masaya Watarai¹  Ichiro Hanamura¹  Akiyoshi Takami¹ 

[1] Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine;Hematopoietic Cell Transplantation Center, Aichi Medical University Hospital;Department of Clinical Laboratory, Aichi Medical University Hospital;Keyaki Clinic;Division of Hematology/chemotherapy, Daido Hospital

关键词: copper deficiency;    cytopenia;    cytoplasmic vacuoles;    zinc supplements;   

DOI  :  10.1002/jha2.278

来源: Wiley

【 摘 要 】

Introduction Due to an increased incidence of copper deficiency, we investigated adult patients who had low serum levels of copper with cytopenia at our hospital from March 2014 to March 2021. Methods We retrospectively reviewed the clinical data of patients who had been diagnosed with cytopenia due to copper deficiency at the Aichi Medical University Hospital from March 2014 to March 2021. Results In the 15 patients with cytopenia secondary to low serum copper level, 11 had cytopenia of two to three lineages; three (27%) had pancytopenia, and eight (73%) had bicytopenia. Of the 15 patients, nine (60%) underwent bone marrow examinations; three (30%) showed typical morphologic features associated with copper deficiency, such as multiple clear cytoplasmic vacuoles in erythroblasts and myeloid cells, and three (30%) showed dysplastic features as observed in myelodysplastic syndrome. Among the 14 (93%) patients who were treated with copper supplements, had cessation of zinc supplements, or both, 11 (73%) and eight (53%) showed normal copper levels and hematological improvement, respectively. Conclusion Copper deficiency is more common than expected and should be considered in patients with unexplained cytopenia.

【 授权许可】

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