De novo large-cell neuroendocrine carcinoma of the prostate: A case report and literature review

IJU Case Reports

article

Eri Fukagawa¹  Takeshi Yuasa¹  Kentaro Inamura⁴  Kosuke Hamada¹  Motohiro Fujiwara¹  Yoshinobu Komai¹  Junji Yonese¹ 

[1] Department of Urology, Cancer Institute Hospital of Japanese Foundation for Cancer Research;Department of Urology, St. Luke's International Hospital;Contribution: Conceptualization, Data curation, Project administration;Department of Pathology, Cancer Institute Hospital of Japanese Foundation for Cancer Research;Contribution: Data curation

关键词: adenocarcinoma;    cell differentiation;    large cell carcinoma;    neuroendocrine carcinoma;    prostate cancer;   

DOI  :  10.1002/iju5.12527

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

Introduction Prostatic large-cell neuroendocrine carcinoma is poorly studied. Although several case reports are available, information on the clinicopathological characteristics of this disease is limited, particularly for the de novo (hormone-naive) type. Herein, we report an extremely rare de novo case of this disease with a good prognosis despite a multi-metastatic status. Case presentation An 83-year-old male patient presented with a high serum prostate-specific antigen level and was found to have de novo prostatic large-cell neuroendocrine carcinoma with an adenocarcinoma component upon pathological examination. Diagnosed with stage pT4cN1cM1c, he underwent chemo-hormonal therapy using a luteinizing hormone-releasing hormone antagonist and combined etoposide and cisplatin, which achieved a partial response. The patient has survived for 20 months without progression. Conclusion Although prostatic large-cell neuroendocrine carcinoma is known for its aggressive clinical behavior, the de novo type with an adenocarcinoma component may be sensitive to hormonal therapy and achieve a good prognosis.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND