Bone marrow metastasis in a patient with non-seminomatous testicular germ cell tumor

IJU Case Reports

article

Takashi Ueda¹  Ippei Takada¹  Teruki Shimizu¹  Saya Ito¹  Atsuko Fujihara¹  Takumi Shiraishi¹  Terukazu Nakamura⁵  Osamu Ukimura¹ 

[1] Department of Urology, Kyoto Prefectural University of Medicine;Contribution: Data curation;Contribution: Writing - review & editing;Contribution: Writing - original draft;Department of Urology, Saiseikai Suita Hospital;Contribution: Supervision

关键词: AFP;    bone marrow metastasis;    desperation RPLND;    salvage chemotherapy;    testicular germ cell tumor;   

DOI  :  10.1002/iju5.12446

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

Introduction Metastasis to the bone marrow is rare in testicular germ cell tumor patients. We report a case of a patient with a non-seminomatous testicular germ cell tumor who presented with bone marrow metastases after intensive chemotherapy. Case presentation A 36-year-old man was admitted to the hospital with pancytopenia. Previously, he had received intensive care for an advanced left testicular germ cell tumor. Although multidisciplinary treatments including several regimens of salvage chemotherapy, desperation retroperitoneal lymph node dissection, and focal radiotherapy were performed, the serum tumor marker alfa-fetoprotein was not normalized and there were no findings of relapse by several imaging modalities. Bone marrow aspirate, conducted to diagnose a cause of pancytopenia, revealed metastatic germ cell tumors in the bone marrow. Conclusion Bone marrow metastasis should be considered as a differential diagnosis in patients with germ cell tumors whose serum tumor makers are not normalized without any radiographic finding of recurrence.

【 授权许可】

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