Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab

IJU Case Reports

article

Yusuke Imamura¹  Shinichi Sakamoto¹  Jun-ichiro Ikeda²  Tomohiko Ichikawa¹  Tomokazu Sazuka¹  Ayumi Fujimoto¹  Hiroaki Sato¹  Takayuki Arai¹ 

[1] Urology, Graduate School of Medicine, Chiba University;Diagnostic Pathology, Graduate School of Medicine, Chiba University

关键词: deferred cytoreductive nephrectomy;    ipilimumab;    nivolumab;    renal cell carcinoma;    tertiary lymphoid structure;   

DOI  :  10.1002/iju5.12347

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

Introduction Tertiary lymphoid structure expression and immune checkpoint inhibitors have been attracting attention, and their relationship with renal cell carcinoma is controversial. Case presentation Two patients with nivolumab plus ipilimumab treatment response for metastatic renal cell carcinoma underwent cytoreductive nephrectomy and regional lymph node dissection. In both cases, the renal tumor site expressed tertiary lymphoid structures. Despite the absence of treatment after a deferred cytoreductive nephrectomy and the short postoperative observation period, the patients still survived. Conclusion Tertiary lymphoid structures were expressed in deferred cytoreductive nephrectomy specimen in cases treated with nivolumab plus ipilimumab.

【 授权许可】

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