Selective Phosphorylation of RNA- and DNA-Nucleosides under Prebiotically Plausible Conditions

ChemSystemsChem

article

Maximilian Bechtel¹  Eva Hümmer¹  Prof. Dr. Oliver Trapp¹ 

[1] Department of Chemistry, Ludwig-Maximilians-University Munich;Max-Planck-Institute for Astronomy

关键词: nucleotides;    origin of life;    phosphorylation;    prebiotic chemistry;    regioselectivity;   

DOI  :  10.1002/syst.202200020

来源: Wiley

【 摘 要 】

Phosphorylation reactions in an aqueous medium on the early Earth: Prebiotically plausible organocatalyst 2,5-dimethylimidazolidine-4-thione is able to function as phosphorylation agent under exceptionally mild reactions conditions in an aqueous mixture without condensation agent. Depending on the surrounding conditions, the stereo selective formation of all canonical non-cyclic mono-phosphorylated nucleosides is possible.

【 授权许可】

Unknown