Reversible Photoswitchable Inhibitors Enable Wavelength-Selective Regulation of Out-of-Equilibrium Bi-enzymatic Systems

ChemSystemsChem

article

Dr. Michael Teders¹  Nicholas R. Murray¹  Prof. Wilhelm T. S. Huck¹ 

[1] Institute for Molecules and Materials, Radboud University Nijmegen

关键词: enzymatic systems;    enzymes;    photochemistry;    photoswitchable inhibitors;    systems chemistry;   

DOI  :  10.1002/syst.202100020

来源: Wiley

【 摘 要 】

Let there be light ! A regulatory strategy enabling to fine-tune the kinetics of enzyme-catalyzed reactions under out-of-equilibrium conditions is exploited. By synthesis and incorporation of reversible photoswitchable inhibitors, the output of bottom-up constructed enzymatic systems could be controlled using light. In addition, two enzymes were independently photoregulated in a bi-enzymatic system using light of different wavelengths.

【 授权许可】

Unknown