The effects of inactivated SARS-CoV-2 vaccination and subsequent infection of pregnant mice on the behaviors of offspring

Animal Models and Experimental Medicine

article

Kaili Lin¹  Meixuan Liu¹  Lu Sun¹  Hongwei Qiao¹  Shunyi Wang¹  Sidan Pan¹  Hanjun Fu¹  Jingzhu Wang¹  Qiang Wei¹  Hong Gao¹ 

[1] Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College

关键词: offspring;    spatial reference memory;    spontaneous locomotor activity;   

DOI  :  10.1002/ame2.12261

学科分类：机械工程学

来源: Wiley

【 摘 要 】

The mass inoculation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines to induce herd immunity is one of the most effective measures we can deploy in the fight against coronavirus disease 2019 (COVID-19). Pregnant women are prone to a higher risk of COVID-19, and maternal infection is a risk factor for a range of neurological disorders leading to abnormal behavior in adulthood. However, there are limited clinical data to support whether vaccination or infection post-immunization in pregnant women can affect the behavioral cognition of fetuses in adulthood. In this study, human angiotensin-converting enzyme 2 pregnant mice (F0 generation) were immunized with CoronaVac and then infected with SARS-CoV-2. Subsequently, we analyzed the behavioral cognition of their adult offspring (F1 generation) using the open-field test and Morris water maze test. The adult F1 generation did not exhibit any impairments in spontaneous locomotor activity or spatial reference memory.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND