Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus

Animal Models and Experimental Medicine

article

Xi Yu¹  Gong Cheng¹ 

[1] Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University;Institute of Infectious Diseases, Shenzhen Bay Laboratory;Institute of Pathogenic Organisms, Shenzhen Center for Disease Control and Prevention;School of Life Sciences, Tsinghua University

关键词: dengue virus (DENV);    evolution;    flavivirus;    phylogenetics;   

DOI  :  10.1002/ame2.12283

学科分类：机械工程学

来源: Wiley

【 摘 要 】

Dengue virus (DENV) is one of the most important arboviral pathogens in the tropics and subtropics, and nearly one-third of the world's population is at risk of infection. The transmission of DENV involves a sylvatic cycle between nonhuman primates (NHP) and Aedes genus mosquitoes, and an endemic cycle between human hosts and predominantly Aedes aegypti . DENV belongs to the genus Flavivirus of the family Flaviviridae and consists of four antigenically distinct serotypes (DENV-1-4). Phylogenetic analyses of DENV have revealed its origin, epidemiology, and the drivers that determine its molecular evolution in nature. This review discusses how phylogenetic research has improved our understanding of DENV evolution and how it affects viral ecology and improved our ability to analyze and predict future DENV emergence.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND