Adaptation of mammals to hypoxia

Animal Models and Experimental Medicine

article

Fang Li¹  Zhenglei Qiao¹  Qijiao Duan²  Eviatar Nevo³ 

[1] College of Life Sciences and Technology, Mudanjiang Normal University;College of Natural Resources and Environment, South China Agriculture University;Institute of Evolution, University of Haifa

关键词: hemoglobin;    high-altitude;    hypoxia;    marine mammals;    subterranean mammals;   

DOI  :  10.1002/ame2.12189

学科分类：机械工程学

来源: Wiley

【 摘 要 】

Oxygen plays a pivotal role in the metabolism and activities of mammals. However, oxygen is restricted in some environments—subterranean burrow systems or habitats at high altitude or deep in the ocean—and this could exert hypoxic stresses such as oxidative damage on organisms living in these environments. In order to cope with these stresses, organisms have evolved specific strategies to adapt to hypoxia, including changes in physiology, gene expression regulation, and genetic mutations. Here, we review how mammals have adapted to the three high-altitude plateaus of the world, the limited oxygen dissolved in deep water habitats, and underground tunnels, with the aim of better understanding the adaptation of mammals to hypoxia.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND