Multifunctional inorganic nanomaterials for cancer photoimmunotherapy

Cancer Communications

article

Lu Tang¹  Aining Zhang¹  Ziyao Zhang¹  Qingqing Zhao¹  Jing Li¹  Yijun Mei¹  Yue Yin¹  Wei Wang¹ 

[1] State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University;National Medical Products Administration Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, China Pharmaceutical University;These authors made equal contributions to this work

关键词: biodegradability;    cancer photoimmunotherapy;    immune stimulation;    inorganic nanomaterial;    nanoparticles;    targeted drug delivery;   

DOI  :  10.1002/cac2.12255

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Phototherapy and immunotherapy in combination is regarded as the ideal therapeutic modality to treat both primary and metastatic tumors. Immunotherapy uses different immunological approaches to stimulate the immune system to identify tumor cells for targeted elimination. Phototherapy destroys the primary tumors by light irradiation, which induces a series of immune responses through triggering immunogenic cancer cell death. Therefore, when integrating immunotherapy with phototherapy, a novel anti-cancer strategy called photoimmunotherapy (PIT) is emerging. This synergistic treatment modality can not only enhance the effectiveness of both therapies but also overcome their inherent limitations, opening a new era for the current anti-cancer therapy. Recently, the advancement of nanomaterials affords a platform for PIT. From all these nanomaterials, inorganic nanomaterials stand out as ideal mediators in PIT due to their unique physiochemical properties. Inorganic nanomaterials can not only serve as carriers to transport immunomodulatory agents in immunotherapy owing to their excellent drug-loading capacity but also function as photothermal agents or photosensitizers in phototherapy because of their great optical characteristics. In this review, the recent advances of multifunctional inorganic nanomaterial-mediated drug delivery and their contributions to cancer PIT will be highlighted.

【 授权许可】

CC BY|CC BY-NC-ND