Harness the functions of gut microbiome in tumorigenesis for cancer treatment

Cancer Communications

article

Mong-Hong Lee¹ 

[1] Research Institute of Gastroenterology, Sun Yat-sen University;Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, the Sixth Affiliated Hospital of Sun Yat-sen University

关键词: cancer biomarkers;    chemotherapy;    fecal microbiota transplantation;    gut microbiome;    immunotherapy;    microbiota;    probiotics;   

DOI  :  10.1002/cac2.12200

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

It has been shown that gut microbiota dysbiosis leads to physiological changes and links to a number of diseases, including cancers. Thus, many cancer categories and treatment regimens should be investigated in the context of the microbiome. Owing to the availability of metagenome sequencing and multiomics studies, analyses of species characterization, host genetic changes, and metabolic profile of gut microbiota have become feasible, which has facilitated an exponential knowledge gain about microbiota composition, taxonomic alterations, and host interactions during tumorigenesis. However, the complexity of the gut microbiota, with a plethora of uncharacterized host-microbe, microbe-microbe, and environmental interactions, still contributes to the challenge of advancing our knowledge of the microbiota-cancer interactions. These interactions manifest in signaling relay, metabolism, immunity, tumor development, genetic instability, sensitivity to cancer chemotherapy and immunotherapy. This review summarizes current studies/molecular mechanisms regarding the association between the gut microbiota and the development of cancers, which provides insights into the therapeutic strategies that could be harnessed for cancer diagnosis, treatment, or prevention.

【 授权许可】

CC BY|CC BY-NC-ND