Incidence of left atrial appendage thrombus despite 3 weeks of anticoagulation and the need for precardioversion echocardiography

Annals of noninvasive electrocardiology: the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

article

Marc Erickson MD¹  Harika Yadav MD²  Eliea Sneij MD²  Jordan Austin DO²  Harish Manyam MD¹ 

[1] Department of Cardiology, University of Tennessee College of Medicine;Department of Internal Medicine, University of Tennessee College of Medicine

关键词: anticoagulation;    atrial fibrillation;    cardioversion;    DOAC;    stroke prevention;    stroke prophylaxis;   

DOI  :  10.1111/anec.12989

来源: Wiley

【 摘 要 】

Background One of the most catastrophic complications of Atrial fibrillation (AF) is thromboembolic stroke. Current guidelines recommend that 3 weeks of anticoagulation is adequate prior to direct current cardioversion (DCCV) to prevent thromboembolism. Here we present data regarding, which anticoagulant is most likely to show a presence of an Left atrial appendage thrombus (LAAT) on trans esophageal echocardiogram (TEE) for DCCV despite 3 weeks of anticoagulation. Objective To investigate the effectiveness of both vitamin k antagonist (VKA) and direct oral anticoagulants (DOAC) in patients with AF as an anticoagulant for LAAT after 3 weeks of medication. Methods This is a single-high volume tertiary center, where TEE precardioversion is the standard practice. We reviewed data over 10 months where DCCV was intended on individuals with AF who were fully anticoagulated for at least 3 weeks with either a VKA or taking a DOAC. Results The data showed a statistical difference between patients who were fully anticoagulated for at least 3 weeks with VKA in comparison to DOACs. Patients on DOACs are significantly less likely to have an LAAT after at least 3 weeks of anticoagulation. OR = 0.04 (CI 95% 0.005–0.42; p -value < .05). Despite anticoagulation for at least 3 weeks, 40% of our patients still had a LAAT. Conclusion Our data indicates that all patients should be required to undergo a TEE prior to DCCV. This data also adds to the current evidence and supports the use of DOAC in AF to prevent LAAT.

【 授权许可】

Unknown