Suppression of amiodarone-induced torsade de pointes by landiolol in a patient with atrial fibrillation-mediated cardiomyopathy

Annals of noninvasive electrocardiology: the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

article

Shigeki Uemura MD¹  Takafumi Okura MD¹  Shuntaro Ikeda MD²  Masafumi Takemoto ME³  Yutaka Utsunomiya ME³  Takashi Hyodo ME³  Koji Takahashi MD²  Mina Yamashita MD¹  Tomoki Sakaue MD²  Daijiro Enomoto MD¹ 

[1] Department of Cardiology, Yawatahama City General Hospital;Department of Community Emergency Medicine, Ehime University Graduate School of Medicine;Department of Medical Engineering, Yawatahama City General Hospital

关键词: amiodarone;    atrial fibrillation;    heart failure;    landiolol;    long QT syndrome;    torsade de pointes;   

DOI  :  10.1111/anec.12842

来源: Wiley

【 摘 要 】

An elderly Japanese woman developed acute decompensated heart failure caused by persistent atrial fibrillation (AF) and left ventricular systolic dysfunction. Approximately 6 days after starting intravenous administration of amiodarone (600 mg/day) for maintaining sinus rhythm after cardioversion of AF, electrocardiograms revealed a prolonged QT interval associated with torsade de pointes (TdP). The amiodarone-induced TdP disappeared after intravenous administration of landiolol plus magnesium and potassium, without discontinuation of amiodarone or overdrive cardiac pacing, although the prolonged QT interval persisted. To the best of our knowledge, this is the first report that landiolol could be effective for amiodarone-induced TdP.

【 授权许可】

Unknown