Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss

Laryngoscope Investigative Otolaryngology

article

Yongzhen Wu MD, PhD¹  Zijun Song MD¹  Yi Wang MD, PhD¹  Hui Zhao MD¹  Tongli Ren MD¹  Jianghua Jing MD¹  Na Gao MD¹  Liang Qiao MD, PhD³  Jing Wang MD, PhD¹ 

[1] Department of Otology and Skull Base Surgery, Eye Ear Nose & Throat Hospital, Fudan University;National Health Commission Key Laboratory of Hearing Medicine;Department of Gastroenterology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

关键词: idiopathic sudden sensorineural hearing loss;    intratympanic steroids;    locally weighted regression;    pure tone audiometry;    salvage treatment;   

DOI  :  10.1002/lio2.909

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Background Salvage intratympanic steroids (ITS) works in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) after failure of initial therapy, but optimal timing of administration is unknown. Methods Two hundred and seventy patients with ISSNHL were included. Among them, 180 were treated with ITS and standard medical treatment (SMT) and the other 90 received SMT along. The hearing threshold before and after salvage treatment were compared. The relationship between the salvage starting time and hearing recovery was analyzed. Results The hearing of ITS group improved more than that of the SMT group in all frequency bands. The effect of both strategies decreases with the delay of the starting time. ITS can improve hearing even if being administrated 5 weeks after onset while SMT failed after 3 weeks. Conclusion Patients with profound ISSNHL can obtain extra hearing recovery from salvage ITS. The earlier salvage starts, the greater the patient benefits.

【 授权许可】

CC BY|CC BY-NC-ND