Histopathological characteristics of larynx in hypothyroidism in an experimental rabbit model

Laryngoscope Investigative Otolaryngology

article

Kamyar Iravani MD¹  Behnaz Golkhar MD¹  Negar Azarpira MD²  Mahsa Kohandel-Shirazi MD³  Mahjoob Vahedi MD⁴ 

[1] Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences;Transplant Research Center, Shiraz Institute of Stem Cell and Regenerative Medicine, Shiraz University of Medical Sciences;Department of Pathology, Shiraz University of Medical Sciences;Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences

关键词: animal model;    histology;    hypothyroidism;    larynx;    voice;   

DOI  :  10.1002/lio2.852

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Objective Hypothyroidism has a significant effect on the patients' voices. This study evaluated the histopathological characteristics of larynx following hypothyroidism in an experimental rabbit model. Methods Eleven male Dutch rabbits were included. Methimazole-induced hypothyroidism was done for nine rabbits. The remaining two rabbits were assigned as controls. Six weeks after starting methimazole, a histological examination was performed with parameters of inflammation, ulceration, hemorrhage, and thickness of epithelium, Reinke's space, vocal ligament, thyroarytenoid muscle, collagen deposition, and periodic acid-Schiff (PAS)-positive materials, as well as confirmation of hypothyroidism by T4 measurement. Results Histologic examination showed a significant thickening of epithelium, Reinke's space, vocal ligament, and collagen PAS-positive materials deposition in hypothyroid rabbits ( p  < .05). There was significant reduction in thyroarytenid muscle thickness ( p  < .05). Inflammation, ulceration, and bleeding were not significantly different between hypothyroid and control rabbits' laryngeal specimens. Conclusion Hypothyroidism causes significant changes in the laryngeal tissues. Thickening of epithelium, Reinke's space, vocal ligament, collagen, PAS-positive materials, and reduced thickness of thyroarytenoid muscle are the major findings of this study.

【 授权许可】

CC BY|CC BY-NC-ND