Environmental air pollution and chronic rhinosinusitis: A systematic review

Laryngoscope Investigative Otolaryngology

article

Evelyn M. Leland BS¹  Varun Vohra BA¹  Stella M. Seal MLS²  Zhenyu Zhang PhD³  Murugappan Ramanathan Jr MD¹ 

[1] Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University;Welch Medical Library, Johns Hopkins University School of Medicine;Department of Global Health, School of Public Health, Peking University;Institute for Global Health and Development, Peking University

关键词: air pollutants;    environmental pollution;    quality of life;    sinusitis;   

DOI  :  10.1002/lio2.774

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Objective Chronic rhinosinusitis (CRS) is a highly prevalent and burdensome disease. The pathophysiology is not fully elucidated, but environmental pollutants have been suggested to impact the inflammatory component of the disease process. This review aims to summarize the role of environmental pollution in CRS onset and disease severity. Methods A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus databases were queried in August 2021. Original articles reporting on air pollution exposure in CRS were included. Other forms of sinonasal disease were excluded. Results Literature search produced 11,983 articles, of which 10 met inclusion criteria. Outcomes evaluated included incidence/prevalence, disease severity, quality of life, and histopathologic/microbial changes. Air pollutant exposure was associated with higher odds of CRS, particularly with particulate matter (PM) exposure. Increasing air pollution exposure was also associated with worsened disease severity and detectable histopathologic changes. Impact on quality of life was less clear. Conclusion Air pollution (particularly PM) is correlated with CRS incidence/prevalence and disease severity, with evidence of histopathologic changes in CRS tissue samples. Further research is warranted to better understand the mechanisms by which air pollution components may cause CRS and type 2 inflammation.

【 授权许可】

CC BY|CC BY-NC-ND