期刊论文详细信息
Laryngoscope Investigative Otolaryngology
High parathyroid hormone levels after parathyroidectomy for parathyroid adenoma are not related to the cellularity of the remaining glands
article
Rotem Sagiv MD1  Bertha Delgado MD2  Re'em Sadeh MD3  Sagi Shashar MD3  Merav Fraenkel MD4  Ksenia M. Yegodayev MSc5  Moshe Elkabets PhD5  Ben-Zion Joshua MD, MBA6 
[1] Joyce & Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev;Pathology Unit, Soroka University Medical Center;Clinical Research Center of Soroka Medical Center;Endocrinology Unit, Soroka University Medical Center;Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev;Department of Otorhinolaryngology – Head and Neck Surgery, Barzilai Medical Center
关键词: cellularity;    elevated PTH levels;    parathyroid adenoma;    parathyroid hyperplasia;    parathyroidectomy;   
DOI  :  10.1002/lio2.644
学科分类:环境科学(综合)
来源: Wiley
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【 摘 要 】

Background Patients with primary hyperparathyroidism (PHPT) treated surgically occasionally have normalized calcium, but persistently high parathyroid hormone (PTH). We hypothesized that a possible explanation for this phenomenon is an underlying hyperplasia rather than adenoma. Methods Retrospective cohort of patients who underwent parathyroidectomy for PHPT with biopsy of a normal-appearing parathyroid gland were included. Cellularity level of each biopsy and of the adenoma's rim was determined. Results Forty-seven patients were included. Of them, 19 (40%) had postoperative normocalcemia but elevated PTH. There was no correlation between cellularity either in the rim or of the normal-appearing parathyroid gland and postoperative PTH. The postoperative high PTH group had higher preoperative PTH ( P  = 0.001) and larger adenomas ( P  = 0.025). Conclusions High PTH levels after successful parathyroidectomy in patients with primary hyperparathyroidism do not appear to result from underlying hyperplasia. A possible alternative explanation is that these patients have a higher preoperative burden of disease.

【 授权许可】

CC BY|CC BY-NC-ND   

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