Normative data for ages 18-45 for ocular motor and vestibular testing using eye tracking

Laryngoscope Investigative Otolaryngology

article

Aura Kullmann PhD¹  Robin C. Ashmore PhD¹  Alexandr Braverman PhD²  Christian Mazur BS¹  Hillary Snapp PhD³  Erin Williams BS³  Mikhaylo Szczupak MD³  Sara Murphy PhD⁴  Kathryn Marshall PhD⁵  James Crawford MD⁶  Carey D. Balaban PhD⁷  Michael Hoffer MD³  Alexander Kiderman PhD¹ 

[1] Neurolign USA LLC, A Subsidiary of Neurolign Technologies Inc. ,(formerly Neuro Kinetics, Inc.);The Hebrew University of Jerusalem;Department of Otolaryngology, Miller School of Medicine, University of Miami;Naval Medical Center;Department of Defense, Hearing Center of Excellence;Madigan Army Medical Center;Department of Otolaryngology, University of Pittsburgh;Department of Neurological Surgery, Miller School of Medicine, University of Miami

关键词: concussion;    eye tracking;    mild traumatic brain injury;    mTBI;    Neurolign Dx 100;    neurological conditions;    NOTC;    rotation tests;    vestibular conditions;   

DOI  :  10.1002/lio2.632

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Objective Eye tracking technology has been employed in assessing ocular motor and vestibular function following vestibular and neurologic conditions, including traumatic brain injury (TBI). Assessments include tests that provide visual and motion (rotation) stimuli while recording horizontal, vertical, and torsional eye movements. While some of these tests have shown diagnostic promise in previous studies, their use in clinical practice is limited by the lack of normative data. The goal of this study was to construct normative reference ranges to be used when comparing patients' results. Methods Optokinetic response, subjective visual horizontal and vertical, and rotation tests were administered to male and female volunteers, ages 18-45, who were free from neurological, vestibular disorders, or other head injuries. Tests were administered using either a rotatory chair or a portable virtual reality-like goggle equipped with video-oculography. Results Reference values for eye movements in response to different patterns of stimuli were analyzed from 290 to 449 participants. Analysis of gender (self-reported) or age when grouped as pediatric (late adolescent; 18-21 years of age) and adult (21-45 years of age) revealed no effects on the test metrics. Data were pooled and presented for each test metric as the 95% reference interval (RI) with 90% confidence intervals (CI) on upper and lower limits of the RI. Conclusions This normative database can serve as a tool to aid in diagnosis, treatment, and/or rehabilitation protocols for vestibular and neurological conditions, including mild TBI (mTBI). This database has been cleared by the FDA for use in clinical practice (K192186).

【 授权许可】

CC BY|CC BY-NC-ND