Combined treatment modality in pediatric infratentorial midline high-grade glioma can lead to long-term survival: A case study and review of literature

Precision Radiation Oncology

article

Chinzah Lalsangzuala¹  Rabi Sahu¹  Suvendu Purkait¹  Dillip Parida¹  Saroj Das Majumdar¹  Sovan Sarang Dhar¹ 

[1] Department of Radiotherapy, Department of Neurosurgery, Department of Pathology, All India Institute of Medical Sciences;Correspondecne;Dr. Sovan Sarang Dhar, Department of Radiotherapy, AIIMS;Email: [e-mail]

关键词: adjuvant chemoradiation;    midline high-grade glioma;    pediatric CNS neoplasm;    survival;   

DOI  :  10.1002/pro6.1127

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

Central nervous system high-grade glioma (HGG) occurring in an infratentorial midline location is not commonly found in the pediatric population. Though pediatric HGGs appear similar to their adult counterparts histopathologically, they differ in molecular, genetic, and clinical characteristics. Evidence for the management of HGG is sparse in the literature. Surgery in the form of maximum safe resection is the backbone of management and has been variably supplemented with external beam radiotherapy and cytotoxic chemotherapy. The outcome, though largely dismal, has some positive surprises too. As shown in the presented case, the combined modality of management in a 5-year-old female child has resulted in a disease-free survival of 3.5 years.

【 授权许可】

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