γδ T cell exhaustion: Opportunities for intervention

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Di Chen¹  Yinglu Guo¹  Jiahuan Jiang²  Pin Wu²  Ting Zhang¹  Qichun Wei¹  Jian Huang²  Dang Wu¹ 

[1] Department of Radiation Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University;Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University;Cancer Institute ,(Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University;Department of Breast Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University;Department of Thoracic Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University

关键词: exhaustion;    immune checkpoints;    immunotherapy;    PD-1;    γδ T cells;   

DOI  :  10.1002/JLB.5MR0722-777R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

T lymphocytes are the key protective contributors in chronic infection and tumor, but experience exhaustion by persistent antigen stimulation. As an unconventional lineage of T cells, γδ T cells can rapidly response to varied infectious and tumor challenges in a non-MHC-restricted manner and play key roles in immune surveillance via pleiotropic effector functions, showing promising as candidates for cellular tumor immunotherapy. Activated γδ T cells can also acquire exhaustion signature with elevated expression of immune checkpoints, such as PD-1, decreased cytokine production, and functional impairment. However, the exhaustion features of γδ T cells are distinct from conventional αβ T cells. Here, we review the researches regarding the characteristics, heterogeneity, and mechanisms of γδ T cell exhaustion. These studies provide insights into the combined strategies to overcome the exhaustion of γδ T cells and enhance antitumor immunity. Summary sentence : Review of the characteristics, heterogeneity, and mechanisms of γδ T cell exhaustion provides insights into the combined strategies to enhance γδ T cell-based antitumor immunotherapy.

【 授权许可】

CC BY