Metabolic impact of adipose tissue macrophages in the early postnatal life

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Tamás Röszer¹ 

[1] Division of Pediatric Obesity, Children's Hospital and Institute of Pediatrics, University of Debrecen;Institute of Neurobiology, Ulm University

关键词: inflammation;    macrophage;    obesity;    pediatric adiposity;   

DOI  :  10.1002/JLB.3MR0722-201R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Adipose tissue macrophages (ATMs) play key roles in metabolic inflammation, insulin resistance, adipose tissue fibrosis, and immune disorders associated with obesity. Research on ATM biology has mostly been conducted in the setting of adult obesity, since adipocyte hypertrophy is associated with a significant increase in ATM number. Signals that control ATM activation toward a proinflammatory or a proresolving phenotype also determine the developmental program and lipid metabolism of adipocytes after birth. ATMs are present at birth and actively participate in the synthesis of mediators, which induce lipolysis, mitobiogenesis, and mitochondrial uncoupling in adipocytes. ATMs in the newborn and the infant promote a lipolytic and fatty acid oxidizing adipocyte phenotype, which is essential to support the lipid-fueled metabolism, to maintain nonshivering thermogenesis and counteract an excessive adipose tissue expansion. Since adipose tissue metabolism in the early postnatal life determines obesity status in adulthood, early-life ATM functions may have a life-long impact.

【 授权许可】

CC BY