Physiologic roles of P2 receptors in leukocytes

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Anael Viana Pinto Alberto¹  Natiele Carla da Silva Ferreira¹  André Gustavo Calvano Bonavita²  Oscar Kenji Nihei³  Fernando Pires de Farias⁴  Rodrigo da Cunha Bisaggio¹  Cristóvão de Albuquerque⁶  Wilson Savino⁷  Robson Coutinho-Silva⁹  Pedro Muanis Persechini^1,10  Luiz Anastacio Alves¹ 

[1] Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation;Laboratory of Bioactive Products, Multidisciplinary Center, Federal University of Rio de Janeiro;Center of Education and Letter, State University of the West of Paraná;Souza Marques School of Medicine, Souza Marques College;Federal Institute of Education, Science;PositivaMente Consulting;Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation;Brazilian National Institute of Science and Technology on Neuroimmunomodulation, Rio de Janeiro Research Network on Neuroinflammation;Laboratory of Immunophysiology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro;Laboratory of Immunobiophysics, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro

关键词: ATP;    glia;    immune cells;    P2X;    P2Y;   

DOI  :  10.1002/JLB.2RU0421-226RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Since their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types. In the immune system, purinergic receptors participate in innate immunity and in the modulation of the adaptive immune response. In particular, P2 receptors, which respond to extracellular nucleotides, are widely expressed on leukocytes, causing the release of cytokines and chemokines and the formation of inflammatory mediators, and inducing phagocytosis, degranulation, and cell death. The activity of these receptors is regulated by ectonucleotidases—expressed in these same cell types—which regulate the availability of nucleotides in the extracellular environment. In this article, we review the characteristics of the main purinergic receptor subtypes present in the immune system, focusing on the P2 family. In addition, we describe the physiologic roles of the P2 receptors already identified in leukocytes and how they can positively or negatively modulate the development of infectious diseases, inflammation, and pain.

【 授权许可】

CC BY