Macrophage orchestration of epithelial and stromal cell homeostasis in the intestine

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Qian Cao¹  Randall Tyler Mertens³  Kisha Nandini Sivanathan³  Xuechun Cai¹  Peng Xiao¹ 

[1] Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine;Inflammatory Bowel Disease Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine;Department of Immunology, Harvard Medical School;Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital;The Key Laboratory for Immunity and Inflammatory Diseases of Zhejiang Province;Institute of Immunology, Zhejiang University School of Medicine

关键词: intestinal epithelial cells;    intestinal inflammation;    macrophages;    mucosal immunity;    stromal cells;   

DOI  :  10.1002/JLB.3RU0322-176R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The intestinal tract is a complex ecosystem where numerous cell types of epithelial, immune, neuronal, and endothelial origin coexist in an intertwined, highly organized manner. The functional equilibrium of the intestine relies heavily on the proper crosstalk and cooperation among each cell population. Furthermore, macrophages are versatile, innate immune cells that participate widely in the modulation of inflammation and tissue remodeling. Emerging evidence suggest that macrophages are central in orchestrating tissue homeostasis. Herein, we describe how macrophages interact with epithelial cells, neurons, and other types of mesenchymal cells under the context of intestinal inflammation, followed by the therapeutic implications of cellular crosstalk pertaining to the treatment of inflammatory bowel disease.

【 授权许可】

CC BY